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Home / Primary Antibodies / Recombinant Antibodies

ARNT Recombinant Monoclonal Antibody (CSB-RA002121A0HU)

SKU : BHA10564584

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-RA002121A0HU
Alternative Names	Aryl hydrocarbon receptor nuclear translocator, ARNT protein, Class E basic helix-loop-helix protein 2, bHLHe2, Dioxin receptor, nuclear translocator, Hypoxia-inducible factor 1-beta, HIF-1-beta, HIF1-beta, ARNT, BHLHE2
Categories	Primary Antibodies
Clonality	monoclonal
Immunogen	A synthesized peptide derived from human ARNT
Isotype	IgG
Reactivity	Human
Relevance	Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28396409).
Subcellular Location	Nucleus

Antigen	ARNT
Uniprot	P27540
Gene Name	ARNT
Database Links	HGNC:700 OMIM:126110 KEGG:hsa:405 STRING:9606.ENSP00000351407 UniGene:Hs.632446
Function	Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.
Pathway	HIF-1 signaling pathway
Research Area	Cardiovascular

Form	Liquid
Purification	Affinity-chromatography
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Description	WB ; ELISA ; IHC ; IP
Tested Application	ELISA, WB, IHC, IP; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200, IP:1:200-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunoprecipitation (IP) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10564584	CSB-RA002121A0HU	50ul	$210		Add to Cart
BHA10564584	CSB-RA002121A0HU	100ul	$350		Add to Cart

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