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Home / Primary Antibodies / Recombinant Antibodies

Anti-PSMA-Anti-CD3 IgG format Bispecific Antibody

SKU : BHA18200131

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BPS Bioscience

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Mfr.No.	101242, 101242-1, 101242-2
Description	Anti-PSMA-Anti-CD3 IgG format bispecific antibody is a purified recombinant human bispecific antibody with T cell Engager. This bispecific antibody has been tested for specific activity in the functional reporter assay using NFAT-luc reporter Jurkat cell line (BPS Bioscience #60621) in the presence of PSMA-CHO cells (BPS Bioscience #79641-H). PSMA (Prostate-Specific Membrane antigen), also known as FOLH1 (folate hydrolase 1) and NAALADase I (N-acetyl-L-aspartyl-L-glutamate peptidase I) is a transmembrane protein highly expressed in the intestine, the prostate, and the nervous system. The protein is a glutamate carboxypeptidase involved in folate metabolism and may be involved in pathological conditions such as hyperhomocysteinemia (intestine) and glutamate toxicity (nervous system). PSMA is overexpressed in prostate cancer cells and is the target of an increasing number of diagnostic and therapeutic approaches used for the treatment of prostate cancer.
Formulation	8 mM phosphate, 110 mM NaCl, 2.2 mM KCl, pH 7.4, and 20% glycerol
Host	HEK293
Isotype	IgG1
Molecular Weight	~150 kDa (Heavy Chain: 50 kDa; Light Chain: 24 kDa)
Shipping	-80°C
Species	Human
Synonyms	PSMA, Prostate-Specific Membrane antigen, FOLH, FOLH1, folate hydrolase 1, NAALAD1, NAALADase I, N-acetyl-L-aspartyl-L-glutamate peptidase I, PSM, FGCP, Glutamate carboxypeptidase, GCP2, membrane glutamate carboxypeptidase, mGCP, GCPII
Note	Waings Avoid freeze/thaw cycles Scientific Category Immunotherapy, CAR-T Regulatory Status Research Use Only

Uniprot	Q04609

Format	Aqueous buffer solution
Purification	Protein A affinity purification of the IgG-tag protein from HEK293 cells.
Purity	≥90%
Storage	At least 12 months at -80°C.

Tested Application	The anti-PSMA-anti-CD3 IgG format bispecific antibody can be used to study PSMA -mediated T cell activation in co-culture assays, using either primary T cells or reporter cell lines such as NFAT-luc-Jurkat cells (BPS Bioscience #60621).

Product Manual	101242 Lot 211109

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SKU	Supplier No.	Szie	Your price	Quantity
BHA18200131	101242, 101242-1, 101242-2	50 µg	$410		Add to Cart
BHA18200131	101242, 101242-1, 101242-2	100 µg	$410		Add to Cart

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