Anti-undefined Antibody VEGI,2052R Unconjugated BHA10208302

Mfr.No.	9966-RBM2-P1ABX
Alternative Names	TNF ligand-related molecule 1 (TL1A) ; Tumor necrosis factor (ligand) superfamily member 15 (TNFSF15) ; Vascular endothelial growth inhibitor 192a ; Vascular endothelial growth inhibitor (VEGI) ; VEGI192A
Categories	Primary Antibodies
Cellular Localization	Secreted, Cell Surface
Chromosome Location	9q32
Clonality	monoclonal
Description	VEGI is an anti-angiogenic cytokine that belongs to tumor necrosis factor superfamily, member 15 (TNFSF15). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of VEGI has been reported as a marker of poor prognosis in breast cancer.
Host	Rabbit
Immunogen	Recombinant full-length human VEGI protein
Isotype	IgG
Positive Control	Endothelial cells. Colon, intestine, placenta, lung, liver, kidney, pancreas, spleen and prostate.
Reactivity	Human
Recombinant	TRUE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	O95150
Gene Id	9966
Clone No	VEGI, 2052R
Symbol	TNFSF15
Weight	22kDa

Buffer	200μg/ml of Ab purified by Protein A Column. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Storage	Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Applications

IHC-F

Description

Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes ,Optimal dilution for a specific application should be determined., IHC-F

Dilution

Immunohistology (Formalin-fixed)

1-2μg/ml for 30 minutes at RT