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Home / Primary Antibodies / Recombinant Antibodies

Anti-CCNB1 Antibody BHA11305101

SKU : BHA11305101

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Mfr.No.	BS6874
Alternative Names	CCNB1 ; CCNB ; cyclin B1 ; G2/mitotic-specific cyclin-B1
Categories	Primary Antibodies
Chromosome Location	5q13.2
Clonality	polyclonal
Description	Cyclins are a family of proteins that activate specific cyclin-dependent kinases required for progression through the cell cycle. The entry of all eukaryotic cells into mitosis is regulated by activation of cdc2/cdk1 at the G2/M transition. This activation is a multi-step process that begins with the binding of the regulatory subunit, cyclin B1, to cdc2/cdk1 to form the mitosis-promoting factor (MPF). MPF remains in the inactive state until phosphorylation of cdc2/cdk1 at Thr161 by cdk activating kinase (CAK) and dephosphorylation of cdc2/cdk1 at Thr14/Tyr15 by cdc25C. Four cyclin B1 phosphorylation sites (Ser126, 128, 133, and 147) are located in the cytoplasmic retention signal (CRS) domain and are thought to regulate the translocation of cyclin B1 to the nucleus at the G2/M checkpoint, promoting nuclear accumulation and initiation of mitosis. While MPF itself can phosphorylate Ser126 and Ser128, polo-like kinase 1 (PLK1) phosphorylates cyclin B1 preferentially at Ser133 and possibly at Ser147. At the end of mitosis, cyclin B1 is targeted for degradation by the anaphase-promoting complex (APC), allowing for cell cycle progression. Research studies have shown that cyclin B1 is overexpressed in breast, prostate, and non-small cell lung cancers.
Host	Rabbit
Immunogen	Recombinant full length Human Cyclin B1.
Reactivity	Human
Recombinant	TRUE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P14635
Uniprot	P14635
Weight	60 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: CCNB1 polyclonal antibody detects endogenous levels of CCNB1 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IF

Description

WB ; IF

Dilution

WB	1:500-1:2000
IF	1:50-1:200

Datasheet

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA11305101	BS6874	50µl	$234.89		Add to Cart
BHA11305101	BS6874	100µl	$368.22		Add to Cart

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