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Home / Primary Antibodies / Polyclonal Antibodies

Rabbit Anti-Rat Aquaporin 2 Polyclonal (SPC-503)

BHA11907900
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Email
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Antigen Aquaporin 2
Swissprot P34080
Accession Number NP_037041.2
Gene Id 25386
Target Aquaporin 2
Research Area Neurotransmission, Ion Channels, Aquaporins, Neuroscience
Buffer PBS, 50% glycerol, 0.09% sodium azide
Concentration 1 mg/ml
Dilutions WB (1:2000), IHC (1:200), ICC/IF (1:400); optimal dilutions for assays should be determined by the user.
Purification Protein A Purified
Scientific Background Aquaporins selectively conduct water molecules in and out of the cell, while preventing the passage of ions and other solutes. Known as water channels, they are integral membrane pore proteins (1, 2). Aquaporin 2 is the vasopressin-regulated water channel of the apical membrane of collecting duct cells. It is located in kidney epithelial cells and usually lies dormant in intracellular vesicle membranes. When it is needed vasopressin binds to the cell surface vasopressin receptor, activating a signaling pathway that cause AQP2 containing vesicles to fuse with the plasma membrane so the AQP2 can be used by the cell (3). Defects in AQP2 area cause of an autosomal dominant form of nephrogenic diabetes insipidus (NDI) (4).
Shipping Temperature Blue Ice or 4°C
Specificity Detects ~28.8kDa. May detect larger glycosylated bands ~35-50kDa.
Storage -20ºC
Storage Buffer PBS, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications IHC, WB, ICC/IF
Description WB ; IHC ; ICC ; IF
Dilution WB (1:2000), IHC (1:200), ICC/IF (1:400); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Reference 1. Gonen T., Walz T. (2006) Q. Rev. Biophys. 39(4): 361-396.

2. Knepper M.A. (1994) Proc Natl. Acad Sci. USA. 91(14): 6255-6258.

3. Lodish H.F. (2008) Molecular Cell Biology. New York: W.H. Freeman. Print. 445.

4. www.vivo.colostate.edu/hbooks/molecules/aquaporins.html
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11907900-1 SPC-503D Unconjugated 100 ug $337
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BHA11907900-2 SPC-503D-A390 ATTO 390 100 ug $392
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BHA11907900-3 SPC-503D-A488 ATTO 488 100 ug $391
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BHA11907900-4 SPC-503D-A594 ATTO 594 100 ug $391
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BHA11907900-5 SPC-503D-APC APC 100 ug $390
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BHA11907900-6 SPC-503D-BI Biotin 100 ug $386
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BHA11907900-7 SPC-503D-FITC FITC 100 ug $381
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BHA11907900-8 SPC-503D-HRP HRP 100 ug $377
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BHA11907900-9 SPC-503D-PCP PerCP 100 ug $390
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BHA11907900-10 SPC-503D-RPE RPE 100 ug $388
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BHA11907900-11 SPC-503S Unconjugated 12 ug $45
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