BubR1 (pSer670)

Mfr.No.	SPC-929, SPC-929D, SPC-929D-A390, SPC-929D-A488, SPC-929D-A594, SPC-929D-BI, SPC-929D-FITC
Immunogen Species	Human
Alternative Names	Beta homolg of S. cerevisiae BUB 1 antibody, Beta homolg of S. cerevisiae budding uninhibited by benzimidazoles antibody, BUB 1B antibody, BUB1 budding uninhibited by benzimidazoles 1 homolog beta antibody, Bub1A antibody, BUB1B antibody, BUB1B_HUMAN antibody, BUB1beta antibody, BUBR1 antibody, Budding Uninhibited by Benzimidazoles 1 beta antibody, Budding uninhibited by benzimidazoles 1 homolog beta (yeast) antibody, hBUBR1 antibody, MAD3/BUB1 related protein kinase antibody, MAD3L antibody, Mitotic checkpoint gene BUB1B antibody, Mitotic checkpoint kinase MAD3L antibody, MVA1 antibody, Protein SSK1 antibody, SSK 1 antibody, SSK1 antibody
Categories	Antibodies
Cellular Localization	Cytoplasm, Nucleus
Certificate Of Analysis	A 1:250 dilution of SPC-929 was sufficient for detection of BubR1 (pSer670) in 10 ug of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Clonality	Polyclonal
Description	Rabbit Anti-Human BubR1 (pSer670) Polyclonal
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Rabbit
Gross Weight (kg)	1.4
Immunogen	A phospho-specific peptide corresponding to residues surrounding Ser670 of human BUBR1 (AA667-673), Homo Sapiens (Human)
Immunogen Region	A phospho-specific peptide corresponding to residues surrounding Ser670 of human BUBR1 (AA667-673)
Launch Date	2016/08/29
Net Weight (g)	0.1
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Human
Tissue Specificity	Highly expressed in thymus followed by spleen. Preferentially expressed in tissues with a high mitotic index.

Antigen	BubR1
Swissprot	O60566
Accession Number	NP_001202
Gene Id	701
Target	BubR1 (pSer670)
Research Area	Cancer, Cell Cycle, Cell Division, Cell Signaling, Epigenetics and Nuclear Signaling, Protein Phosphorylation

Buffer	PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Dilutions	WB (1:250); optimal dilutions for assays should be determined by the user.
Purification	Peptide Affinity Purified
Purity	Highly expressed in thymus followed by spleen. Preferentially expressed in tissues with a high mitotic index.
Scientific Background	BUBR1 is a protein-serine/threonine kinase. It is an essential component of mitotic checkpoint. It prevents progression of anaphase until all the sister chomatids are connected to spindles by binding to CDC20 to anaphase promoting complex/cycolsome thus inhibiting it. It is also involved in localization of CENPE, a kinetochore motor that performs kinetochore functions. Other functions include suppression of centrosome amplification, negative regulation of PLK1 in intephase and trigger apoptosis in polyploid cells.
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects 119 kDa.
Storage	-20ºC
Storage Buffer	PBS pH7.4, 50% glycerol, 0.025% Thimerosal *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	AM, WB
Description	WB ; AM
Dilution	WB (1:250); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11911538-1	SPC-929D	Unconjugated	100 ul	$338	Add to Cart
BHA11911538-2	SPC-929D-A390	ATTO 390	100 ul	$393	Add to Cart
BHA11911538-3	SPC-929D-A488	ATTO 488	100 ul	$392	Add to Cart
BHA11911538-4	SPC-929D-A594	ATTO 594	100 ul	$392	Add to Cart
BHA11911538-5	SPC-929D-BI	Biotin	100 ul	$388	Add to Cart
BHA11911538-6	SPC-929D-FITC	FITC	100 ul	$383	Add to Cart

Rabbit Anti-Human BubR1 (pSer670) Polyclonal (SPC-929)

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