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Home / Proteins & Peptide

Zika Virus Ns2B-Ns3 (S2) protein

SKU : BHP20900036

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Mfr.No.	0555-001
Description	The Zika Virus NS2B-NS3 (S2) protein is a highly purified recombinant protein designed for advanced virology research. This protein plays a critical role in viral replication, serving as a target for drug discovery and therapeutic interventions. It functions as a serine protease, facilitating the cleavage of viral polyproteins essential for replication and maturation. Expressed in Drosophila S2 cells using the ExpreS2™ system and purified via column chromatography, the NS2B-NS3 protease complex is a reliable resource for understanding Zika virus pathogenesis. Key Advantages High Purity: Greater than 95% as confirmed by SDS-PAGE and HPLC. Functional Integrity: Verified protease activity for reliable experimental outcomes with consistent performance in inhibitor screening assays. Ease of Use: Supplied in a ready-to-use liquid format in PBS. Flexible Applications: Suitable for structural studies, enzymatic assays, and drug discovery research. Reproducibility: Produced under stringent quality control to ensure batch-to-batch consistency. Endotoxin-Free: Guaranteed for sensitive applications.
Product Type	Other Viruses
Features	Origin: Recombinant Zika Virus NS2B-NS3 (S2) protein. Expression System: Drosophila S2 insect cells using ExpreS2™ technology, optimizing post-translational modifications. Purification: Multi-step column chromatography ensuring high purity and activity. Molecular Weight: 26.8 kDa (theoretical). Format: Liquid in phosphate-buffered saline (PBS). Storage: Store at -80°C for long-term stability; aliquot to avoid freeze-thaw cycles.
Application	Protease Activity Studies: The Zika virus NS2B-NS3 protease has been widely studied for its enzymatic mechanisms. For instance, NS2B-NS3 protease activity has been analyzed using fluorogenic and chromogenic substrates to better understand its catalytic properties and interactions (Xing et al.). Inhibitor Screening: High-throughput methods have identified promising small molecules and peptides that inhibit NS2B-NS3 activity. Notable studies highlight potential antiviral candidates and computational screening methods to design effective inhibitors (Hossain et al.; Nascimento et al.). Structural Biology: Structural studies, including crystallography and NMR, have resolved the protease's configuration and provided insights into the molecular basis of inhibitor binding, critical for drug design (Zhang et al.; Penna et al.). Viral Pathogenesis Research: NS2B-NS3 plays a vital role in Zika virus replication and interaction with host cellular machinery. Research has elucidated its dual functionality, offering insights into viral replication and pathogenesis (Shiryaev et al.). High-Throughput Screening: Assay platforms leveraging the NS2B-NS3 protease have been developed to facilitate drug discovery efforts. Such platforms have proven effective for rapid evaluation of antiviral compounds (Li et al.).
Purification	Column chromatography
Abbreviation	Zika Ns2B-Ns3 dimer (S2)
Expression	S2 cells

Target Details	Zika virus Ns2B-Ns3 dimer
Target Pathogen	Zika Virus

Shipping	1 week

Applications	WB

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SKU	Supplier No.	Size	Your price	Quantity
BHP20900036	0555-001	100 ug	$570.94		Add to Cart

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