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Home / Proteins & Peptide

WKYMVm

SKU : BHP21300066

A Potent Agonist of FPR2 and FPR3 G-Protein Coupled Receptors

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Mfr.No.	GPW-105, GPW-105_0.5 mg, GPW-105_1 mg, GPW-105_10 mg, GPW-105_5 mg
Description	A Potent Agonist of FPR2 and FPR3 G-Protein Coupled Receptors
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C41H61N9O7S2
Background	Chemotactic factors from both Gram-positive and Gram-negative bacteria are short peptides with N-formyl methionine at the N-terminus (extensively reviewed in reference 1). These peptides are released from bacteria during infection and activate formyl peptide receptors (FPR), members of the G-protein coupled receptor (GPCR) superfamily. In humans, the FPR family consists mainly of three receptors, FPR1, FPR2/ALX (formerly FPRL1), and FPR3 (formerly FPRL2) which all couple to the Gi subtype of G-proteins and ultimately lead to the activation of phospholipase C and intracellular Ca2+ increase1,2.WKYMVm is a selective agonist of the Formyl peptide receptors (FPR2 and FPR3) and was discovered by screening peptide libraries for their ability to stimulate inositol phosphates in lymphocyte cell lines3,4. It is also an agonist of FPR11. FPR2 is expressed in the promyelocytic leukemia cell line HL-60 as well as in the chronic myelogenous leukemia cell line K5625.WKYMVm inhibited the infection of human peripheral monocyte-derived macrophages and CD41 T lymphocytes by strains of HIV-1, via sensitization of chemokine receptors (CXCR4 and CCR5), following FPR2 activation6.
Biological Activity	WKYMVm is a selective agonist of the formyl peptide receptors (FPR2 and FPR3) and was discovered by screening peptide libraries for their ability to stimulate inositol phosphates in lymphocyte cell lines1,2.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	856.11 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Concentration	1 nM - 10 uM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: No
Cas Number	187986-17-0
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Met6 - D form and C-terminal amidation

Synonyms	Trp-Lys-Tyr-Met-Val-D-Met-NH2, Leukocyte chemoattractant peptide
Gene Id	FPR2, FPR3
Sequence	WKYMVM-NH2
Target	FPR2, FPR3 receptors

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Calcium imaging assay

Reference	Le, Y. et al. (2002) Trends Immunol. 23, 541. Le, Y. et al. (1999) J. Immunol. 163, 6777. Christophe, T. et al. (2001) J. Biol. Chem. 276, 21585. See Applications for Anti-Human FPR2/ALX (extracellular) Antibody. Li, B.Q. et al. (2001) Blood 97, 2941. Ye, R.D. et al. (2009) Pharmacol. Rev. 61, 119. Christophe, T. et al. (2001) J. Biol. Chem. 276, 21585. Le, Y. et al. (1999) J. Immunol. 163, 6777.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300066-1	GPW-105_0.5 mg	0.5 mg	$55		Add to Cart
BHP21300066-2	GPW-105_1 mg	1 mg	$75		Add to Cart
BHP21300066-3	GPW-105_10 mg	10 mg	$432		Add to Cart
BHP21300066-4	GPW-105_5 mg	5 mg	$243		Add to Cart

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