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Home / Proteins & Peptide

Waglerin-1

SKU : BHP21300308

A Potent Antagonist of nAChR and a Modulator of GABA(A) Receptors

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Mfr.No.	STW-001, STW-001_1 mg, STW-001_10 mg, STW-001_25 mg, STW-001_5 mg
Description	A Potent Antagonist of nAChR and a Modulator of GABA(A) Receptors
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C112H175N37O26S2
Background	Waglerin-1 is a 22 amino acid peptide toxin isolated from the Southeast Asian snake Trimeresurus wagleri1. Two other similar peptides named Waglerin-2 and 3 are isolated from the same snake species1.Waglerin-1 selectively blocks the nAChRepsilon subunit with an IC50 of 50 nM2 and is a potent blocker of muscle nAChR3. Waglerin-1 is also a modulator of GABA(A) receptors with potentiating and suppressing effects. Its IC50 and EC50 value is 24 uM4.
Biological Activity	Waglerin-1 blocks epsilon subunit of muscle adult nAChR and modulates rodent GABA(A)/GABRA1 receptors1,2.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	2520 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P24335
Concentration	1- 5 uM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
Cas Number	145038-84-2
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bond between: Cys9-Cys13
Origin	Tropidolaemus wagleri (Wagler's pit viper) (Trimeresurus wagleri)

Synonyms	Waglerin-I, Wtx-1, Lethal peptide I
Gene Id	CHRNA1,CHRNB1,CHRND,CHRNE,GABR
Sequence	GGKPDLRPCHPPCHYIPRPKPR-OH
Target	nAChR, GABA(A) receptors

Country Of Origin	Israel/IL
Purity	>=99% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Sellin, L.C. et al. (1996) Biophys. J. 70, 3. McArdle, J.J. et al. (1999) J. Pharmacol. Exp. Ther. 289, 543. Molles, B.E. et al. (2002) J. Biol. Chem. 277, 5433. Ye, J.H. and McArdle, J.J. (1997) J. Pharmacol. Exp. Ther. 282, 74. McArdle, J.J. et al. (1999) J. Pharmacol. Exp. Ther. 289, 543. Molles, B.E. et al. (2002) J. Biol. Chem. 277, 5433

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300308-1	STW-001_1 mg	1 mg	$134		Add to Cart
BHP21300308-2	STW-001_10 mg	10 mg	$638		Add to Cart
BHP21300308-3	STW-001_25 mg	25 mg	$1114		Add to Cart
BHP21300308-4	STW-001_5 mg	5 mg	$459		Add to Cart

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