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Home / Proteins & Peptide

VEGF121, Human

SKU : BHP18500301

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iXCells Biotechnologies

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Mfr.No.	IX03140, IX03140-10, IX03140-50
Description	VEGF-A121 is one of five isoforms (121, 145, 165, 189, and 206) of VEGF protein, a cytokine belonging to the Platelet Differentiation Growth Factor (PDGF) family, and existing as a disulfide-linked homodimeric glycoprotein. In contrast to the longer isoforms, VEGF-A121 is more freely diffusible, and cannot bind to heparin. In vivo, VEGF is expressed predominantly in lung, heart, kidney, and adrenal glands, and the expression of VEGF is up-regulated by a number of growth factors, including PDGF, Fibroblast Growth Factor (FGF), Epidermal Growth Factor (EGF), and Tumor Necrosis Factor (TNF). VEGF signals via binding to two tyrosine kinase receptors: the Fms-like tyrosine kinase 1 (Flt-1) and the kinase domain receptor (KDR). VEGF is a specific mitogen and survival factor, contributing to abnormal angiogenesis and cancer development. Recombinant human VEGF-A121 (rhVEGF-A121) produced in E. coli is a disulfide-linked homodimer containing two non-glycosylated polypeptide chains of 121 amino acids each. A fully biologically active molecule, rhVEGF-A121 has a molecular mass of 28.2 kDa analyzed by non-reducing SDS-PAGE and is obtained by proprietary chromatographic techniques.
Reconstitution	Reconstituted in ddH2O or PBS at 100 ug/ml.
Formulation	Lyophilized after extensive dialysis against PBS.
Molecular Weight	28.2 kDa, observed by non-reducing SDS-PAGE.
Source	E. coli
Host	Human
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	ED50 5 ng/mL, measured by a cell proliferation assay using HUVEC Cells, corresponding to a specific activity of 2x 105 units/mg.

Synonyms	Vascular Endothelial Growth Factor121, VPF
Sequence	MPMAEGGGQN HHEVVKFMDV YQRSYCHPIE TLVDIFQEYPDEIEYIFKPS CVPLMRCGGC CNDEGLECVP TEESNITMQIMRIKPHQGQH IGEMSFLQHN KCECRPKKDR ARQEKCDKPRR

Purity	95% as analyzed by SDS-PAGE and HPLC.
Storage	Lyophilized recombinant human VEGF-A121 (rhVEGF-A121) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rhVEGF-A121 remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500301-1	IX03140-10	10ug	$107		Add to Cart
BHP18500301-2	IX03140-50	50ug	$344		Add to Cart

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