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Home / Proteins & Peptide

u-Conotoxin PIIIA

SKU : BHP21300164

A Potent Blocker of NaV1.2, NaV1.4 and NaV1.7 Na+ Channels

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Mfr.No.	STC-400, STC-400_0.1 mg, STC-400_0.25 mg, STC-400_0.5 mg, STC-400_1 mg, STC-400_10 mg, STC-400_5 mg
Description	A Potent Blocker of NaV1.2, NaV1.4 and NaV1.7 Na+ Channels
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C103H166N40O28S6
Background	u-Conotoxin PIIIA is a 22 amino acid peptidyl toxin isolated from the Conus purpurascens (Purple cone) venom and belongs to the conotoxin M superfamily1. It reversibly blocks mammalian skeletal muscle voltage-gated Na+ channels (NaV1.4, IC50 of 44 nM), Type II (NaV1.2) and PN1 (NaV1.7) neuronal voltage-gated Na+ channels (IC50 of 640 nM) by binding to site I domain of the channel1-3. In addition, it irreversibly blocks amphibian muscle Na+ channels1.
Biological Activity	u-Conotoxin PIIIA reversibly blocks mammalian skeletal muscle voltage-gated Na+ channels (NaV1.4, IC50 of 44 nM), Type II (NaV1.2) and PN1 (NaV1.7) neuronal voltage-gated Na+ channels (IC50 of 640 nM) by binding to site I domain of the channel. In addition, it blocks irreversibly amphibian muscle Na+ channels1.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	2604 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P58925
Concentration	10 nM - 1 uM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys4-Cys16, Cys5-Cys21, and Cys11-Cys22 Cys22 - C-terminal amidation. Pro8 , Pro18 - Hydroxyprolines Q1 - Pyrrolidone carboxylic acid (Glp)
Origin	Conus purpurascens (Purple cone)

Synonyms	u-Conotoxin P3.7
Gene Id	SCN1A,SCN2A,SCN3A,SCN4A,SCN8A,SCN9A
Sequence	QRLCCGFPKSCRSRQCKPHRCC-NH2
Target	Various NaV channels

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Nielsen, K.J. et al. (2002) J. Biol. Chem. 277, 27247. Safo, P. et al. (2000) J. Neurosci. 20, 76. Shon, K.J. et al. (1998) J. Neuroscience 18, 4473. Shon, K.J. et al. (1998) J. Neuroscience 18, 4473.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300164-1	STC-400_0.1 mg	0.1 mg	$130		Add to Cart
BHP21300164-2	STC-400_0.25 mg	0.25 mg	$262		Add to Cart
BHP21300164-3	STC-400_0.5 mg	0.5 mg	$419		Add to Cart
BHP21300164-4	STC-400_1 mg	1 mg	$670		Add to Cart
BHP21300164-5	STC-400_10 mg	10 mg	$3278		Add to Cart
BHP21300164-6	STC-400_5 mg	5 mg	$2342		Add to Cart

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