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Home / Proteins & Peptide

Spike Trimer (S1+S2) (K417T, E484K, N501Y), His- Tag (SARS-CoV-2)

SKU : BHP18201328

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BPS Bioscience

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Mfr.No.	100988-1
Description	Recombinant SARS-CoV-2 Spike protein in its homotrimeric form, containing S1+S2 subunits and encompassing amino acids 16-1213. This protein contains three mutations: K417T, E484K and N501Y that have been found in emerging SARS-CoV-2 Variants of Concern and may lead to higher transmissibility and infectivity. This mutant Spike Trimer will be useful for structure-function studies, testing of neutralizing antibodies, or antibody and drug screening. The construct also contains a C-terminal His-tag. Note that the expected MW of the S1+S2 monomer is 136kDa but migrates at a higher MW in SDS-PAGE due to glycosylation. The recombinant protein is 90% pure following affinity purification.
Immunogen Region	16-1213
Tag	C-terminal His-tag
Formulation	8 mM phosphate pH 7.4, 110 mM NaCl, 2.2 mM KCl, 20% glycerol
Species	SARS-CoV-2
Notes	Avoid freeze/thaw cycles.
GenBank	MN908947
Mw(kda)	137 kDa +glycans

Synonyms	coronavirus, covid, covid-19, covid19, Sars-cov-2 p1, sars cov 2 Spike, sarscov2, SARS-CoV-2 variant b11281, SARS-CoV-2 variant b1135, K417T mutation, Brazil coronavirus, SARS-CoV-2 Brazil, B1135 variant, South Africa variant, 100988-1, 100988-2

Shipping Temperature	-80°C (dry ice)
Purity	>90%
Storage	At least 6 months at -80°C.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18201328	100988-1	100 ug	$352		Add to Cart

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