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Home / Proteins & Peptide

Spike S1 (B.1.351), Avi-His-Tag (SARS-CoV-2)

SKU : BHP18201333

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BPS Bioscience

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Mfr.No.	100992-2
Description	Recombinant SARS-CoV-2 Spike protein, S1 subunit encompassing amino acids 16-685. This protein corresponds to SARS-CoV-2 Variant B.1.351 originally identified in South Africa and contains mutations L18F, D80A, D215G, R246I, K417N, E484K, N501Y, D614G. It also contains a C-terminal Avi-Tag followed by a C-terminal His-tag (6xHis). The recombinant protein is>=90% pure following affinity purification.
Background	SARS-COV-2 Variant B.1.351 was first identified in the fall of 2020 in the Republic of South Africa. This variant, also known as 501Y.V2, has many mutations which may lead to higher transmissibility and infectivity. In particular, the B.1.351 variant contains three mutations within the RBD region of the Spike S1 protein: K417N, E484K, and N501Y. Investigating the effect of mutations on viral replication and pathogenesis will be critical for developing effective strategies for vaccines and antibody therapies against COVID-19.
Immunogen Region	16-685
Tag	C-terminal Avi-His-Tag
Formulation	8mM phosphate pH 7.4, 110mM NaCl, 2.2mM KCl, and 20% glycerol.
Species	SARS-CoV-2
Notes	Avoid freeze/thaw cycles.
GenBank	MN908947
Mw(kda)	78 kDa + glycans

Synonyms	coronavirus, covid, covid-19, covid19, 501Y.V2, sars cov 2, sarscov2, South Africa mutation, South African variant, B1135 enzyme, 100992-1, 100992-2
Uniprot	P0DTC2

Shipping Temperature	-80°C (dry ice)
Purity	>=90%
Storage	At least 6 months at -80°C.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18201333	100992-2	1 mg	$3135		Add to Cart

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