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Home / Proteins & Peptide

SLIGKV-NH2

SKU : BHP21300064

A Potent Agonist of PAR2, Derived from PAR2 Auto-Ligand Sequence

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Mfr.No.	GPS-100, GPS-100_1 mg, GPS-100_100 mg, GPS-100_25 mg, GPS-100_5 mg
Description	A Potent Agonist of PAR2, Derived from PAR2 Auto-Ligand Sequence
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C28H54N8O7
Background	Protease-activated receptors (PARs) 1-4 belong to the superfamily of G-protein-coupled receptors (GPCRs) that are self-activated by a tethered sequence exposed by proteolysis of an extracellular domain1. PARs are activated by proteolysis in response to endogenous and exogenous proteases and can contribute to both cellular homeostasis and pathology1-2. In the case of PAR2, the exposed human peptide SLIGVK-NH2 remains tethered on the receptor and activates a primary binding site located on second loop of the receptor1. As an obvious consequence of its activation mechanism, PAR2 is associated with pathologies with a strong protease release. The involvement of PAR2 in inflammatory diseases such as arthritis, lung inflammation (asthma), inflammatory bowel disease, sepsis, and pain disorders4-6 makes PAR2 an attractive target for drug intervention3. The extracellular N-terminus of PAR2 (46 residues long) contains a putative trypsin cleavage site R34 and S351, followed by LIGKV. The human-derived SLIGKV-NH2 is a small peptide that mimics the ligand binding properties of the tethered ligand exposed by proteolysis of the N-terminus from the natural receptor7 and hence, a significant tool used to study PAR2.
Biological Activity	SLIGKV-NH2 is a selective agonist of the Protease-activated receptor-2 (PAR2)1. The peptide is composed of the neo-N-terminal 6 amino acids of human PAR2, after receptor activation by protease cleavage1.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	614.77 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Concentration	10 - 250 uM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: No
Cas Number	190383-13-2
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Val6 - C-terminal amidation

Synonyms	PAR2 agonist, PAR2AP
Gene Id	F2RL1
Sequence	SLIGKV-NH2
Target	Protease-activated receptor-2 (PAR2)

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Western blot

Reference	Ossovskaya VS. et al. (2004) Physiol Rev. 84, 579. Rattenholl A. et al. (2008) Drug News Perspect. 21, 369. Boitano S. et al. (2011) J. Med. Chem. 54, 1308. Barry GD. et al. (2006) Curr. Med. Chem. 13, 243. Steinhoff M. et al. (2005) Endocr. Rev. 26, 1. Cottrell GS. et al. (2003) Biochem. Soc. Trans. 31, 1191. Ramachandran R. et al. (2008) Br. J. Pharmacol. 153, S263. Ossovskaya V. S. and Bunnett N. W. (2004) Physiol. Rev. 84, 579.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300064-1	GPS-100_1 mg	1 mg	$61		Add to Cart
BHP21300064-2	GPS-100_100 mg	100 mg	$571		Add to Cart
BHP21300064-3	GPS-100_25 mg	25 mg	$273		Add to Cart
BHP21300064-4	GPS-100_5 mg	5 mg	$103		Add to Cart

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