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Home / Proteins & Peptide

Sarafotoxin S6b

SKU : BHP21300114

A Non-Selective and Potent Agonist of Endothelin Receptors

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Mfr.No.	SPE-160, SPE-160_0.1 mg, SPE-160_0.5 mg, SPE-160_1 mg, SPE-160_10 mg, SPE-160_5 mg
Description	A Non-Selective and Potent Agonist of Endothelin Receptors
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C110H159N27O34S5
Background	Sarafotoxin S6b is a non-selective potent endothelin receptor agonist designed from the Lys-2-Arg-1 dipeptide of the endothelin pro-sequence. Sarafotoxin S6b has the ability to induce contractions of the human isolated coronary artery1,2.Studies have shown that acute infusion of an ET-B receptor agonist into the rat renal medulla leads to natriuresis and diuresis via a mechanism that is NOS1-dependent3. Thus, endothelin receptors pharmacology play an important role in studying the function of the receptors.Endothelin receptors include two subtypes: ET-A and ET-B. They are widely distributed in vascular and nonvascular tissues. ETA receptors are predominantly expressed in peripheral tissues, especially in vascular smooth muscle tissues to mediate vasoconstriction. They are also detected in several different regions of the brain. ET-A receptor has high affinity for endothelin-1 and endothelin-2 and relatively low affinity for endothelin-3, while ET-B receptor has equally high affinity for all endothelin isopeptides4.
Biological Activity	Sarafotoxin S6b is an endothelin receptor agonist1,2.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	2564 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P13208
Concentration	1 pM - 100 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
Cas Number	116303-65-2
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys1-Cys15 and Cys3-Cys11
Origin	Atractaspis engaddensis (Israeli burrowing asp) (Israeli mole viper)

Synonyms	SRTX-B, S6B, Sarafotoxin-B
Gene Id	EDNRA, EDNRB
Sequence	CSCKDMTDKECLYFCHQDVIW-OH
Target	Endothelin receptors

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Aequorin functional assay, Calcium imaging assay

Reference	Bax, W.A. et al. (1994) Br. J. Pharmacol. 113, 1471. Aumelas, A. et al. (1999) Eur. J. Biochem. 266, 977. Davenport, A.P. et al. (2016) Pharmacol. Rev. 68, 357. Saeki, T. et al. (1991) Biochem. Biophys. Res. Commun. 179, 286. Bax, W.A. et al. (1994) Br. J. Pharmacol. 113, 1471. Maggi, C.A. et al. (1990) Gen. Pharmacol. 21, 247.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300114-1	SPE-160_0.1 mg	0.1 mg	$117		Add to Cart
BHP21300114-2	SPE-160_0.5 mg	0.5 mg	$168		Add to Cart
BHP21300114-3	SPE-160_1 mg	1 mg	$287		Add to Cart
BHP21300114-4	SPE-160_10 mg	10 mg	$1354		Add to Cart
BHP21300114-5	SPE-160_5 mg	5 mg	$980		Add to Cart

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