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Recombinant Shigella flexneri serotype X E3 ubiquitin-protein ligase ipaH9.8(ipaH9.8)

SKU : BHP10502655

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-YP513237SZC
Alternative Names	Invasion plasmid antigen ipaH9.8
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway and modulates the acute inflammatory responses, thus facilitating bacterial colonization within the host cell. Interacts with IKBKG (NO) and TNIP1 (ABIN-1), a ubiquitin-binding adapter protein, which results in TNIP1-dependent 'Lys-27'-linked polyubiquitination of IKBKG. Consequently, polyubiquitinated IKBKG undergoes proteasome-dependent degradation, which perturbs NF-kappa-B activation during bacterial infection. Uses UBE2D2 (UBCH5B) as an E2 ubiquitin-conjugating enzyme. Mediates polyubiquitination of host U2AF1, leading to its proteasomal degradation.
Source	Yeast
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: E3 ubiquitin-protein ligase ipaH9.8 EC= 6.3.2.-Alternative name(s): Invasion plasmid antigen ipaH9.8
Expression Region	1-545aa
Mol Weight	64.0kDa
Nature	recombinant
Protein Description	Full Length

Subcellular Location	Secreted, Host cytoplasm, Host nucleus
Uniprot	Q8VSC3, D2AJU0
Database Links	KEGG:sfe:SFxv_5076
Function	Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway and modulates the acute inflammatory responses, thus facilitating bacterial colonization within the host cell.
Protein Families	LRR-containing bacterial E3 ligase family
Research Area	Others
Weight	64kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

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SKU	Supplier No.	Size	Your price	Quantity
BHP10502655	CSB-YP513237SZC	500ug	$1916		Add to Cart
BHP10502655	CSB-YP513237SZC	100ug	$826		Add to Cart
BHP10502655	CSB-YP513237SZC	20ug	$436		Add to Cart

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