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Home / Proteins & Peptide

Recombinant SARS-CoV-2 Spike RBD Protein (C-6His-Avi)(Omicron), Biotinylated

SKU : BHP10306478

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSV030479
Reconstitution	Not Applicable
Background	The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that SARS-CoV-2 (COVID-19 coronavirus, 2019-nCoV) can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.
Tag	C-6His-Avi
Formulation	Supplied as a 0.2 um filtered solution of PBS, pH 7.4
Species	SARS-CoV-2
Host	HEK293 Cells
Accession Number	YP_009724390.1
Endotoxin Level	< 1.0 EU per ug protein as determined by the LAL method.
Accurate Molecular Mass(kd)	28kDa
Predicted Molecular Mass(kd)	32-40kDa
Protein Description	Biotinylated Recombinant SARS-CoV-2 S protein RBD Protein is produced by our Mammalian expression system and the target gene encoding Arg319-Phe541 (G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H) is expressed with a 6His, Avi tag at the C-terminus. The mutations were identified in the SARS-CoV-2 variant (known as Omicron/B.1.1.529 lineage) which emerged in South Africa.

Synonyms	S protein RBD; 2019-nCoV S protein RBD; SARS-CoV-2 Spike RBD; Omicron Spike RBD
Research Area	Virus related Protein
Sequence	Arg319-Phe541(G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H)

Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
Purity	> 95 % as determined by SDS-PAGE.
Storage	Store at< -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Immunological Activity	Testing in progress

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SKU	Supplier No.	Size	Your price	Quantity
BHP10306478	PKSV030479	100ug	$1105		Add to Cart

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