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Home / Proteins & Peptide

Recombinant Rhesus macaque HVEM/TNFRSF14/CD270 Protein (Fc Tag)

SKU : BHP10306190

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSQ050075
Description	Recombinant Rhesus macaque HVEM is produced by our Mammalian expression system and the target gene encoding Pro37-Val203 is expressed with a Fc tag at the C-terminus.
Alternative Names	Tumor Necrosis Factor Receptor Superfamily Member 14; Herpes Virus Entry Mediator A; Herpesvirus Entry Mediator A; HveA; Tumor Necrosis Factor Receptor-Like 2; TR2; CD270; TNFRSF14; HVEA; HVEM
Reconstitution	Please refer to the printed manual for detailed information.
Background	Herpesvirus entry mediator (HVEM) is a type I membrane protein in the TNF receptor superfamily, and it can both promote and inhibit T cell activity. HVEM is highly expressed on na?ve CD4+ T cells, CD8+ T memory cells, regulatory T cells, dendritic cells, monocytes, and neutrophils. It functions as a receptor for BTLA, CD160, LIGHT/TNFSF14, and Lymphotoxin-alpha. Ligation of HVEM by LIGHT triggers T cell, monocyte, and neutrophil activation and contributes to Th1 inflammation and cardiac allograft rejection. In contrast, HVEM binding to CD160 or BTLA suppresses T cell and dendritic cell activation and dampens intestinal inflammation. HVEM enhances the development of CD8+ T cell memory and Treg function. It is additionally expressed on intestinal epithelial cells, where its binding by intraepithelial lymphocyte (IEL) expressed CD160 promotes epitheilal integrity and host defense. The herpesvirus envelope glycoprotein gD, which binds HVEM to initiate membrane fusion, can antagonize both BTLA and LIGHT binding.
Reactivity	Rhesus macaque
Tag	C-Fc
Formulation	Lyophilized from a 0.2 um filtered solution of PBS,pH 7.4.
Host	Human Cells
Accession Number	XP_005545061.1
Endotoxin Level	< 1.0 EU per ?g as determined by the LAL method.
Mol Weight	44.7 kDa
Mw(kda)	44.7 kDa

Sequence Info	Pro37-Val203

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 95% as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10306190	PKSQ050075	10ug	$86		Add to Cart
BHP10306190	PKSQ050075	50ug	-		Add to Cart

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