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Home / Proteins & Peptide

Recombinant Rat CCL5/RANTES Protein (His Tag)

SKU : BHP10305831

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSR030422
Alternative Names	C-C motif chemokine 5; SIS-delta; Small-inducible cytokine A5; T-cell-specific protein RANTES; Ccl5; Scya5
Reconstitution	Please refer to the printed manual for detailed information.
Background	C-C motif chemokine 5(CCL5) is a beta-chemokine that plays a primary role in the inflammatory immune response by means of its ability to attract and activate leukocytes. CCL5 is secreted by many cell types at inflammatory sites, and it exerts a wide range of activities through the receptors CCR1, CCR3, CCR4, and CCR5. Inflammatory responses can be impaired by the sequestration of CCL5 by the cytomegalovirus protein US28. Oligomerization of CCL5 on glycosaminoglycans is required for CCR1mediated leukocyte adhesion and activation as well as CCL5s interaction with the chemokine CXCL4/PF4.The deposition of CCL5 on activated vascular endothelial cells is crucial for monocyte adhesion to damaged vasculature, but CCL5 oligomerization is not required for the extravasation of adherent leukocytes.CCL5 is upregulated in breast cancer and promotes tumor progression through the attraction of proinflammatory macrophages in addition to its actions on tumor cells, stromal cells, and the vasculature.
Reactivity	Rat
Tag	N-6His
Description	Recombinant Rat C-C motif chemokine 5 is produced by our E.coli expression system and the target gene encoding Ser25-Ser92 is expressed with a 6His tag at the N-terminus.
Formulation	Lyophilized from a 0.2 um filtered solution of 20mM PB, 500mM NaCl, 2mM EDTA, pH7.4 .
Host	E.coli
Accession Number	P50231
Endotoxin Level	<1.0 EU per ?g as determined by LAL test.
Mol Weight	10 kDa
Mw(kda)	10 kDa

Sequence Info	Ser25-Ser92

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 95 % as determined by SDS-PAGE

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10305831	PKSR030422	10ug	$111		Add to Cart
BHP10305831	PKSR030422	50ug	$297		Add to Cart

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