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Home / Proteins & Peptide

Recombinant Mouse SLC3A2/CD98 Protein (His Tag)

SKU : BHP10301300

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSM040473
Alternative Names	4F2 ; 4F2HC ; AI314110 ; Cd98 ; Ly-10 ; Ly-m10 ; Ly10 ; Mdu1 ; Mgp-2hc ; NACAE
Antigen	SLC3A2 / CD98
Background	4F2 cell-surface antigen heavy chain, also known as 4F2 heavy chain antigen, Lymphocyte activation antigen 4F2 large subunit, CD98, SLC3A2 and MDU1, is a single-pass type I I membrane protein which belongs to the SLC3A transporter family. SLC3A2/ MDU1 is expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. During gestation, expression in the placenta is significantly stronger at full-term than at the mid-trimester stage. SLC3A2/ MDU1 is expressed in HUVECS and at low levels in resting peripheral blood T-lymphocytes and quiescent fibroblasts. It is expressed in fetal liver and in the astrocytic process of primary astrocytic gliomas. SLC3A2/ MDU1 is also expressed in retinal endothelial cells and in the intestinal epithelial cell line Caco2-BBE. SLC3A2/ MDU1 is required for the function of light chain amino-acid transporters. It involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. SLC3A2/ MDU1 is involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7, SLC3A2/ MDU1 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. SLC3A2/ MDU1 plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. It is required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, SLC3A2/ MDU1 is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta.
Tag	His tag
Description	A DNA sequence encoding the extracellular domain of mouse SLC3A2 (NP_001154885.1) (Ala 139-Ala 565) was fused with a polyhistidine tag at the N-terminus.
Regulatory	RUO
Host	Human Cells
Endotoxin Level	< 1.0 EU per μg of the protein as determined by the LAL method
Nature	Recombinant

Shipping	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Buffer	Lyophilized from sterile PBS, pH 7.4
Description	Please refer to the printed manual for detailed information.
Purity	> 98 % as determined by SDS-PAGE
Expiry Date	Samples are stable for up to twelve months from date of receipt at -70℃

Immunogen Species	Mus Musculus (Mouse)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10301300	PKSM040473	50ug	$732		Add to Cart

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