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Home / Proteins & Peptide

Recombinant Mouse Siglec-E (C-Fc)

SKU : BHP10305683

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSM041446
Alternative Names	SiglecE; Siglec-E; Sialic Acid Binding Ig-like Lectin E
Reconstitution	Please refer to the printed manual for detailed information.
Background	Siglecs are sialic acid specific I?type lectins that are characterized by an extracellular domain (ECD) with an N?terminal Ig?like V?set domain followed by varying numbers of Ig?like C2?set domains. Mouse Siglec?E, also known as Myeloid Inhibitory Siglec (MIS), is an 80 ? 85 kDa member of the CD33?related subfamily of Siglecs. Rodent and primate Siglec gene families have significantly diverged, and Siglec?9 is the most likely human ortholog of mouse Siglec?E. Siglec?E is expressed as a heavily N?glycosylated disulfide?linked homodimer and shows binding preference for disialic acids in the alpha 2?8 linkage. Siglec?E is up?regulated and additionally phosphorylated following cellular stimulation by a variety of TLR agonists. Siglec?E signaling negatively regulates the LPS?induced production of TNF? alpha and IL?6 by macrophages. Its up?regulation in macrophages parallels the development of endotoxin tolerance. Siglec?E recognition of sialylated determinants on virulent T. cruzi contributes to the suppression of dendritic cell IL?12 p40 production.
Reactivity	Mouse
Tag	C-Fc
Description	Recombinant Mouse Sialic Acid Binding Ig-like Lectin E is produced by our Mammalian expression system and the target gene encoding Gln20-Phe355 is expressed with a Fc tag at the C-terminus.
Formulation	Lyophilized from a 0.2 um filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.5.
Host	Human Cells
Accession Number	Q6PJ50
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Mol Weight	64.4 kDa
Mw(kda)	64.4 kDa

Sequence Info	Gln20-Phe355

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	>95% as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10305683	PKSM041446	10ug	$217		Add to Cart
BHP10305683	PKSM041446	50ug	$651		Add to Cart

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