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Home / Proteins & Peptide

Recombinant Mouse Serine/threonine-protein kinase VRK1(Vrk1)

SKU : BHP10504921

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-YP768902MOb1
Description	Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity
Alternative Names	Serine/threonine-protein kinase 51PK, Vaccinia-related kinase 1, Serine/threonine-protein kinase 51PK Vaccinia-related kinase 1
Tag	N-terminal 10xHis-tagged and C-terminal Myc-tagged
Regulatory	RUO
Relevance	Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity
Source	Yeast
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	1-140aa
Mol Weight	53.7kDa
Nature	Recombinant
Protein Description	Full Length

Subcellular Location	Cytoplasm, Nucleus, Cytoplasm, cytoskeleton, spindle
Uniprot	Q80X41, Q80X41
Database Links	KEGG:mmu:22367 STRING:10090.ENSMUSP00000021539 UniGene:Mm.2981
Function	Serine/threonine kinase involved in Golgi disassembly during the cell cycle
Protein Families	Protein kinase superfamily, CK1 Ser/Thr protein kinase family, VRK subfamily
Research Area	Cell Biology
Tissue Specificity	Highly expressed in testis. Expressed in liver, kidney and muscle. Weakly expressed in thymus, bone marrow and spleen.
Weight	53.7 kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 85% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Mus Musculus (Mouse)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10504921	CSB-YP768902MOb1	1mg	$2474		Add to Cart
BHP10504921	CSB-YP768902MOb1	100ug	$576		Add to Cart
BHP10504921	CSB-YP768902MOb1	20ug	$306		Add to Cart

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