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Home / Proteins & Peptide

Recombinant Mouse OSMR/IL-31RB Protein (His Tag)

SKU : BHP10305122

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSM040647
Alternative Names	OSMRB
Reconstitution	Please refer to the printed manual for detailed information.
Background	Oncostatin-M specific receptor subunit beta also known as the oncostatin M receptor (OSMR) and Interleukin-31 receptor subunit beta (IL-31RB), is one of the receptor proteins for oncostatin M. OSMR is a member of the type I cytokine receptor family. IL-31RB/OSMR heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in IL-31RB/OSMR have been associated with familial primary localized cutaneous amyloidosis. Defects in IL-31RB/OSMR are the cause of amyloidosis primary localized cutaneous type 1 (PLCA1), also known as familial lichen amyloidosis or familial cutaneous lichen amyloidosis. PLCA1 is a hereditary primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening (lichenification) that may be exacerbated by chronic scratching and rubbing. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins.
Reactivity	Mouse
Tag	C-His
Description	A DNA sequence encoding the mouse OSMR (O70458-1) extracellular domain (Met 1-Leu 738) was expressed, fused with a polyhistidine tag at the C-terminus.
Formulation	Lyophilized from sterile PBS, pH 7.4
Host	HEK293 Cells
Accession Number	O70458-1
Endotoxin Level	< 1.0 EU per ?g of the protein as determined by the LAL method.
Mol Weight	83.7 kDa
Mw(kda)	83.7 kDa

Sequence Info	Met 1-Leu 738

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 97 % as determined by SDS-PAGE

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10305122	PKSM040647	200ug	$940		Add to Cart
BHP10305122	PKSM040647	1mg	-		Add to Cart

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