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Home / Proteins & Peptide

Recombinant Mouse MAG/Siglec-4a Protein (ECD, Fc Tag)

SKU : BHP10305031

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSM040314
Alternative Names	Myelin-Associated Glycoprotein;MAG;Siglec-4a
Reconstitution	Please refer to the printed manual for detailed information.
Background	The myelin-associated glycoprotein (MAG) contains five immunoglobulin-like domains and belongs to the sialic-acid-binding subgroup of the Ig superfamily. MAG is a transmembrane glycoprotein of 100kDa localized in myelin sheaths of periaxonal Schwann cell and oligodendroglial membranes where it functions in glia-axon interactions. It appears to function both as a receptor for an axonal signal that promotes the differentiation, maintenance and survival of oligodendrocytes and as a ligand for an axonal receptor that is needed for the maintence of myelinated axons. MAG contains a carbohydrate epitope shared with other glycoconjugates that is a target antigen in autoimmune peripheral neuropathy associated with IgM gammopathy and has been implicated in a dying back oligodendrogliopathy in multiple sclerosis. MAG is considered as a transmembrane protein of both CNS and PNS myelin and it strongly inhibits neurite outgrowth in both developing cerebellar and adult dosal root ganglion neurons. In contrast, MAG promotes neurite outgrowth from newborn DRG neurons. Thus, MAG may be responsible for the lack of CNS nerve regeneration and may influce both temporally and spatially regeneration in the PNS.
Reactivity	Mouse
Tag	C-Fc
Description	A DNA sequence encoding the mouse Mag (NP_034888.1) (Met1-Pro516) was expressed with the Fc region of human IgG1 at the C-terminus.
Formulation	Lyophilized from sterile PBS, pH 7.4
Host	HEK293 Cells
Accession Number	NP_034888.1
Endotoxin Level	< 1.0 EU per ?g of the protein as determined by the LAL method.
Mol Weight	81.6 kDa
Mw(kda)	81.6 kDa

Sequence Info	Met1-Pro516

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 95 % as determined by SDS-PAGE

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10305031	PKSM040314	100ug	$805		Add to Cart

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