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Home / Proteins & Peptide

Recombinant Mouse Endostatin (C-6His)

SKU : BHP15200193

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ELK Biotechnology

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Mfr.No.	EPT193
Description	Recombinant Mouse Collagen Alpha-1(XVIII) Chain is produced by our Mammalian expression system and the target gene encoding His1591-Lys1774 is expressed with a 6His tag at the C-terminus.
Alternative Names	antiangiogenic agent;COL18A1;collagen alpha-1(XVIII)chain; collagen;type XVIII;Endostatin
Background	Endostatin, an endogenous non?glycosylated inhibitor of endothelial cell proliferation and angiogenesis. It is produced and/or trimmed by metalloproteinases such as MMP?2 and MMP?9, and cathepsins S, B and L. The N?terminal ~27 aa of Endostatin appear to contain the majority of its activity. This region contains zinc binding sites that are thought to be critical for its anti?endothelial and anti?tumor effects, as well as multiple cleavage sites that, when used, can modify its activity. Mouse Endostatin shares 96% aa sequence identity with rat and 85?87% with human, bovine and equine Endostatin. It is predominantly expressed in liver, kidney, lung, skeletal muscle and testis. Endostatin inhibits endothelial cell growth by inducing cell cycle arrest in G1 phase and initiating apoptosis. It is also thought to down?regulate angiogenesis by blocking VEGF?induced endothelial cell migration. Endostatin may also be involved with down?regulation of angiogenesis after establishment of placental circulation in the pregnant uterus.
Molecular Weight	21.2 KDa
Accession Number	P39061
Endotoxin Level	Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
Notes	Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100ug/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Purity	Greater than 95%
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

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SKU	Supplier No.	Size	Your price	Quantity
BHP15200193	EPT193	10ug	$169		Add to Cart

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