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Home / Proteins & Peptide

Recombinant Mouse CD155/PVR Protein (aa 29-348, His Tag)(Active)

SKU : BHP10305474

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSM041230
Alternative Names	Poliovirus receptor; CD155 antigen; Nectin-like protein 5; Nectin-2; Tage4 receptor; Pvr; PVR; Necl5; CD155;3830421F03Rik;D7Ertd458e;HVED;mE4;necl-5;PVS;Taa1;Tage4
Reconstitution	Please refer to it for detailed information.
Background	Mouse poliovirus receptor (PVR, CD155) is a type I transmembrane (TM) glycoprotein that is a member of the nectin-related family of adhesion proteins within the immunoglobulin superfamily. It binds other molecules including vitronectin, Nectin3, DNAM1, CD96, and TIGIT, but does not bind homotypically. CD155 includes a 28 aa signal sequence, a 318 aa extracellular domain (ECD) with one N-terminal V-type and two C2-type Ig-like domains, a 24 aa TM segment and a 38 aa cytoplasmic tail. Epithelial, endothelial, and many immune cells show low CD155 expression. It is up-regulated on endothelia by IFNgamma, and is highly expressed on immature thymocytes, lymph node dendritic cells, and tumor cells of epithelial and neuronal origin. On migrating cells, it is concentrated at the leading edge, where it binds basement membrane vitronectin, recruits Nectin-3-expressing cells, and cooperates with PDGF and integrin alphavbeta3 to promote cell migration. Binding of monocyte DNAM-1 to endothelial cell CD155 promotes transendothelial migration. Enhanced CD155 expression in tumor cells contributes to loss of contact inhibition and increased migration, but also allows tumor cell recognition and killing by DNAM-1or CD96 expressing NK cells.
Reactivity	Mouse
Tag	C-6His
Description	Recombinant Mouse Poliovirus Receptor is produced by our Mammalian expression system and the target gene encoding Asp29-Leu348 is expressed with a 6His tag at the C-terminus.
Formulation	Lyophilized from a 0.2 um filtered solution of PBS, pH7.4.
Host	Human Cells
Accession Number	Q8K094
Endotoxin Level	< 1.0 EU per ?g as determined by the LAL method.
Bioactivity	Immobilized Human TIGIT-Fc(Cat: PKSH033510) at 5ug/ml(100 ul/well) can bind Mouse PVR-6His. The ED50 of Mouse PVR-6His is 35.3 ug/mL
Mol Weight	35.6 kDa
Mw(kda)	35.6 kDa

Sequence Info	Asp29-Leu348

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 95 % as determined by SDS-PAGE

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10305474	PKSM041230	10ug	$117		Add to Cart
BHP10305474	PKSM041230	50ug	$297		Add to Cart

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