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Home / Proteins & Peptide

Recombinant MCP-2/CCL8, Human

SKU : BHP11300113

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Mfr.No.	BK0126‐1mg
Alternative Names	Monocyte Chemoattractant Protein-2 ; HC14 ; SCYA8
Antigen	MCP-2/CCL8
Description	MCP-2 is a member of the chemokines, a group of 70-80 residue proteins sharing substantial sequence similarity. Within the chemokines, MCP-2 belongs to the CC subfamily, and is a member of the Monocyte Chemoattractant Proteins (MCPs), which includes MCP-1, MCP-2, MCP-3, MCP-4, and MCP-5. MCP-2 shares 60% homology with MCP-1, and both proteins can undergo reversible dimerization. The main receptors of MCP-2 are G-protein coupled receptors CCR1 and CCR5. MCP-2 is a potential target in HIV-1 infected human glial cells as it may play a role in the modulation of viral spread in the brain. Recently, researchers found that mouse MCP-2 is expressed in the skin as a novel agonist of CCR8 and plays a role in eosinophilic inflammation.Recombinant human MCP-2/CCL8(rhMCP-2) produced in E.coli is a single non-glycosylated polypeptide chain containing 76 amino acids. A fully biologically active molecule, rhMCP-2 has a molecular mass of 8.9kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.
Regulatory	RUO
Source	Escherichia coli.
Host	Human
Endotoxin Level	< 0.2 EU/μg, determined by LAL method.
Biological Activity Comment	ED50< 0.5 µg/mL, measured by the FLIPR assay using CHO cells transfected with human CCR5, the receptor of human CCL8, corresponding to a specific activity of > 2 × 10ˆ3 units/mg.
Nature	Recombinant

Weight	8.9 kDa, observed by reducing SDS-PAGE.

Description	Reconstituted in ddH2O at 100 μg/mL.
Format	Lyophilized after extensive dialysis against PBS. Sterile Filtered White lyophilized (freeze-dried) powder.
Purity	> 95% by SDS-PAGE analysis.
Storage	Lyophilized recombinant human MCP-2/CCL8(rhMCP-2) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhMCP-2 remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.

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SKU	Supplier No.	Size	Your price	Quantity
BHP11300113	BK0126‐1mg	1mg	$2055.56		Add to Cart
BHP11300113	BK0126‐1mg	25μg	$290		Add to Cart
BHP11300113	BK0126‐1mg	5μg	$173.16		Add to Cart

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