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Recombinant Macaca fascicularis T-cell surface glycoprotein CD3 gamma chain(CD3G),partial

BHP10503368
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Email
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Subcellular Location Cell membrane, Single-pass type I membrane protein
Uniprot Q95LI7, Q95LI7
Database Links

KEGG:mcf:102134381

UniGene:Mfa.6116
Function Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G.
Pathway Hematopoietic cell lineage; T cell receptor signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation
Research Area Immunology
Weight 12.53kDa
Stotage Note Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer Tris-based buffer，50% glycerol
Purity Greater than 90% as determined by SDS-PAGE.
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer Tris-based buffer,50% glycerol
Immunogen Species Monkey
SKU Supplier No. Size Your price Quantity
BHP10503368 CSB-YP850179MOV 100ug $826
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BHP10503368 CSB-YP850179MOV 20ug $436
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