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Home / Proteins & Peptide / Recombinant Protein

Recombinant Human Tumor necrosis factor (TNF), partial (Active)

BHP10506624
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Involvement In Disease Psoriatic arthritis (PSORAS)
Subcellular Location Cell membrane, Single-pass type II membrane protein, SUBCELLULAR LOCATION: Tumor necrosis factor, membrane form: Membrane, Single-pass type II membrane protein, SUBCELLULAR LOCATION: Tumor necrosis factor, soluble form: Secreted, SUBCELLULAR LOCATION: C-domain 1: Secreted, SUBCELLULAR LOCATION: C-domain 2: Secreted
Uniprot P01375
Database Links

HGNC:11892

OMIM:191160

KEGG:hsa:7124

STRING:9606.ENSP00000398698

UniGene:Hs.241570
Function Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective
Pathway MAPK signaling pathway; mTOR signaling pathway; TGF-beta signaling pathway; NF-kappa B signaling pathway; TNF signaling pathway; Apoptosis; Necroptosis; Antigen processing and presentation; Fc epsilon RI signaling pathway; Hematopoietic cell lineage; IL-17 signaling pathway; Natural killer cell mediated cytotoxicity; NOD-like receptor signaling pathway; Osteoclast differentiation; T cell receptor signaling pathway; Toll-like receptor signaling pathway; Adipocytokine signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Inflammatory Pain
Protein Families Tumor necrosis factor family
Research Area Cancer
Antigen TNF
Purity Greater than 95% as determined by SDS-PAGE.
Storage Buffer Lyophilized from a 0.2 μm filtered 20 mM PB, 150 mM NaCl, pH 7.0
Immunogen Species Homo Sapiens (Human)
SKU Supplier No. Size Your price Quantity
BHP10506624 CSB-AP004861HU 10ug $116
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BHP10506624 CSB-AP004861HU 50ug $232
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BHP10506624 CSB-AP004861HU 500ug $1218
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BHP10506624 CSB-AP004861HU 1mg $1740
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