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Home / Proteins & Peptide

Recombinant Human TNF alpha

SKU : BHP15200038

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ELK Biotechnology

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Mfr.No.	EPT038
Description	Recombinant Human Tumor Necrosis Factor Alpha is produced by our E.coli expression system and the target gene encoding Val77-Leu233 is expressed.
Alternative Names	Tumor Necrosis Factor; Cachectin; TNF-Alpha; Tumor Necrosis Factor Ligand Superfamily Member 2; TNF-a; TNF; TNFA; TNFSF2
Background	TNFalpha is a homotrimer with a subunit molecular mass of 17 kD cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It plays a major role in growth regulation, differentiation, inflammation, viral replication, tumorigenesis, autoimmune diseases and in viral, bacterial, fungal, and parasitic infections. Besides inducing hemorrhagic necrosis of tumors, TNF was found to be involved in tumorigenesis, tumor metastasis, viral replication, septic shock, fever, inflammation, and autoimmune diseases including Crohn s disease, and rheumatoid arthritis as well as graft-versus-host disease.
Biological Activity	Measured in a cytotoxicity assay using L?929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D. The ED50 for this effect is 10-50 pg/ml.
Molecular Weight	17.5 KDa
Accession Number	P01375
Endotoxin Level	Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
Notes	Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100ug/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Purity	Greater than 95%
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

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SKU	Supplier No.	Size	Your price	Quantity
BHP15200038	EPT038	50ug	$229		Add to Cart

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