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Recombinant Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 2(TAB2),partial

BHP10506554
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Involvement In Disease Congenital heart defects, multiple types, 2 (CHTD2)
Subcellular Location Membrane, Peripheral membrane protein, Cytoplasm, cytosol
Uniprot Q9NYJ8
Database Links

HGNC:17075

OMIM:605101

KEGG:hsa:23118

STRING:9606.ENSP00000286332

UniGene:Hs.269775
Function Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development.
Pathway MAPK signaling pathway; NF-kappa B signaling pathway; TNF signaling pathway; IL-17 signaling pathway; NOD-like receptor signaling pathway; Osteoclast differentiation; Toll-like receptor signaling pathway
Research Area Immunology
Tissue Specificity Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves.
Purity Greater than 85% as determined by SDS-PAGE.
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
Storage Buffer Tris-based buffer，50% glycerol
Immunogen Species Homo Sapiens (Human)
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BHP10506554 CSB-BP868358HU 100ug $1478
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BHP10506554 CSB-BP868358HU 20ug $528
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