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Home / Proteins & Peptide

Recombinant Human TGF Beta-3 (TGFB3)

SKU : BHP10900217

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Z103065
Alternative Names	ARVD ; LDS5 ; RNHF ; ARVD1. ; Transforming growth factor beta 3
Antigen	TGFB3
Description	Transforming Growth Factor Beta-3 is one of the isoforms of the highly pleiotropic cytokines that are secreted by all cell types. TGF Beta-1, TGF Beta-2, and TGF Beta-3 use the same receptor and act as cellular switches that regulate cell growth, proliferation, differentiation, motility, extracellular matrix synthesis, and immune function regulation. Defects of this gene can cause arrhythmogenic right ventricular dysplasia 1 and rienhoff syndrome. TGFB3 first interacts with the accessory receptor betaglycan (TGF Beta-R3) and a type II serine/threonine kinase receptor (TGF Beta-R2). The receptor then activates a type I serine/threonine kinase receptor such as ALK-1 or TGF Beta-R1 (ALK-5) through phosphorylation, and the activated type I receptor activates Smad proteins to regulate transcription. Recombinant TGF beta 3 is expressed from human 293 cells as a mature disulfide-linked homodimer with a molecular mass of 25 kDa.
Quantity	5 µg
Regulatory	RUO
Source	HEK293
Host	Human
Endotoxin Level	<1 EU/µg of recombinant protein as determined by the LAL method
Biological Activity Comment	The EC(50) as determined by the dose-dependent inhibition of IL-4 induced proliferation of mouse HT-2 cells (BALB/c spleen activated by sheep erythrocytes in the presence of IL-2) was found to be ≤ 0.5 ng/mL.

Weight	25 kDa, homodimer, nonglycosylated

Description	A quick spin of the vial followed by reconstitution in sterile 4 mM HCl containing 0.1% endotoxin-free recombinant human serum albumin (HSA).
Format	Lyophilized Powder 50 mM NaOAc pH 3.7
Purity	>95% as determined by SDS-PAGE
Storage	The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months. Avoid repeated freeze/thaw cycles.

Immunogen Species	Homo Sapiens (Human)

MSDS	Growth Factors, Cytokines & Kinases MSDS
Other	Growth Factor and Cytokine Brochure

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SKU	Supplier No.	Size	Your price	Quantity
BHP10900217	Z103065	5µg	$344.44		Add to Cart

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