Suppressor of cytokine signaling 3, also known as SOCS-3, Cytokine-inducible SH2 protein 3, CIS-3, STAT-induced STAT inhibitor 3, SOCS3 and CIS3, is a protein which is widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. SOCS3/ CIS3 contains one SH2 domain and one SOCS box domain. SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3/ CIS3 is involved in negative regulation of cytokines that signal through the JAK/ STAT pathway. SOCS3/ CIS3 inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. SOCS3/ CIS3 suppresses fetal liver erythropoiesis. It regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. SOCS3/ CIS3 regulates IL-6 signaling. SOCS3/ CIS3 interacts with multiple activated proteins of the tyrosine kinase signaling pathway including IGF1 receptor, insulin receptor and JAK2. SOCS3/ CIS3 could be used as a possible therapeutic agent for treating rheumatoid arthritis.
Tag
His tag ; Trx tag
Description
A DNA sequence encoding the human SOCS3 (O14543) (Met 1-Leu 225) was fused with a Trx and a polyhistide tag at the N-terminus.
Regulatory
RUO
Host
E. coli
Nature
Recombinant
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Buffer
Lyophilized from sterile 50mM Tris, pH 8.0
Description
Please refer to the printed manual for detailed information.
Purity
> 95 % as determined by SDS-PAGE
Expiry Date
Samples are stable for up to twelve months from date of receipt at -70℃
Immunogen Species
Homo Sapiens (Human)
Attachment
Reviews of Recombinant Human SOCS3/CIS3 Protein (His & Trx Tag)