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Home / Proteins & Peptide

Recombinant Human SLAMF5/CD84 Protein (aa 22-220, His Tag)

SKU : BHP10304054

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH033062
Alternative Names	SLAM family member 5; Cell surface antigen MAX.3; Hly9-beta; Leukocyte differentiation antigen CD84; Signaling lymphocytic activation molecule 5; CD84; SLAMF5;hCD84;LY9B;mCD84
Reconstitution	Please refer to the printed manual for detailed information.
Background	SLAM family member 5 (SLAMF5/CD84) is a type I transmembrane protein in the SLAM subgroup of the CD2 family. SLAM family proteins regulate multiple aspects of immune system function. Mature human CD84 consists of a 204 amino acid (aa) extracellular domain (ECD) with two Iglike domains,a 21 aa transmembrane segment, and a 99 aa cytoplasmic domain with two immunoreceptor tyrosinebased switch motifs (ITSMs). CD84 exhibits homophilic binding which is mediated by the N-terminal Ig-like domain. Ligation induces tyrosine phosphorylation in the cytoplasmic ITSMs which then recruit the signaling adaptor molecules SAP (SLAM-associated protein) and EAT-2(EWS/Fli1-activated transcript 2).CD84 signaling inhibits Fc epsilon RI-induced mast cell activation but enhances platelet activation. LPS-induced macrophage activation,T cell proliferation and IFN-gammaproduction, and the interactions between T cells and B cells that are required for germinal center formation.
Reactivity	Human
Tag	C-6His
Description	Recombinant Human SLAM Family Member 5 is produced by our Mammalian expression system and the target gene encoding Lys22-Arg220 is expressed with a 6His tag at the C-terminus.
Formulation	Lyophilized from a 0.2 um filtered solution of PBS, pH7.4.
Host	Human Cells
Accession Number	Q9UIB8
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Mol Weight	23.1 kDa
Mw(kda)	23.1 kDa

Sequence Info	Lys22-Arg220

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 95 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10304054	PKSH033062	10ug	$111		Add to Cart
BHP10304054	PKSH033062	50ug	$297		Add to Cart

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