Tumor necrosis factor receptor superfamily member 19L; TNFRSF19L; Receptor expressed in lymphoid tissues; RELT
Reconstitution
Please refer to the printed manual for detailed information.
Background
Receptor expressed in lymphoid tissues (RELT); also known as tumor necrosis factor receptor superfamily; member 19-like (TNFRSF19L); is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1. RELT/TNFRSF19L is capable of stimulating T-cell proliferation in the presence of CD3 signaling; which suggests its regulatory role in immune response. RELT/TNFRSF19L is a type I transmembrane glycoprotein with a cysteine-rich extracellular domain; possessing significant homology to other members of the TNFR superfamily; especially TNFRSF19; DR3; OX40; and LTbeta receptor. RELT/TNFRSF19L is able to activate the NF-kappaB pathway and selectively binds tumor necrosis factor receptor-associated factor 1. RELT/TNFRSF19L is able to activate the NF-κB pathway and selectively binds tumor necrosis factor receptor-associated factor 1. Although the soluble form of RELT fusion protein does not inhibit the one-way mixed lymphocyte reaction; immobilized RELT/TNFRSF19L is capable of costimulating T-cell proliferation in the presence of CD3 signaling.
Reactivity
Human
Tag
C-His
Description
A DNA sequence encoding the human RELT (NP_116260.2) extracellular domain (Met 1-Ala 160) was fused with a polyhistidine tag at the C-terminus; with 127R/G & 129R/G mutations.
Formulation
Lyophilized from sterile PBS; pH 7.4
Host
HEK293 Cells
Accession Number
NP_116260.2
Endotoxin Level
< 1.0 EU per ug of the protein as determined by the LAL method.
Mol Weight
15.7 kDa
Mw(kda)
15.7 kDa
Sequence Info
Met 1-Ala 160
Shipping
This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.