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Home / Proteins & Peptide

Recombinant Human Reelin(RELN),partial

SKU : BHP10502458

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-YP019557HU
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Extracellular domain matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it ses to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the Extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation .
Source	Yeast
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Reelin; EC= 3.4.21.-
Expression Region	26-254aa
Mol Weight	26.9kDa
Nature	recombinant
Protein Description	Partial

Involvement In Disease	Lissencephaly 2 (LIS2); Epilepsy, familial temporal lobe, 7 (ETL7)
Subcellular Location	Secreted, extracellular space, extracellular matrix
Uniprot	P78509, P78509
Database Links	HGNC:9957 OMIM:257320 KEGG:hsa:5649 STRING:9606.ENSP00000392423 UniGene:Hs.655654
Function	Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation (By similarity).
Pathway	PI3K-Akt signaling pathway; Focal adhesion
Protein Families	Reelin family
Research Area	Cell Adhesion
Tissue Specificity	Abundantly produced during brain ontogenesis by the Cajal-Retzius cells and other pioneer neurons located in the telencephalic marginal zone and by granule cells of the external granular layer of the cerebellum. In adult brain, preferentially expressed in
Weight	26.9kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10502458	CSB-YP019557HU	500ug	$1298		Add to Cart
BHP10502458	CSB-YP019557HU	100ug	$470		Add to Cart
BHP10502458	CSB-YP019557HU	20ug	$250		Add to Cart

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