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Home / Proteins & Peptide

Recombinant Human PI3K (p110 alpha/p85 alpha) (N-His tag)

SKU : BHP10900511

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Z500289
Alternative Names	p110α: PIK3CA ; MGC142161 ; MGC142163 ; p110-alpha
Tag	N-His tag
Description	The PI3K comprises of a 110 kDa catalytic subunit and a 85 kDa regulatory subunit. A number of isoforms of the 110 kDa catalytic subunit and the 85 kDa regulatory subunit exist in cells. The p110a catalytic subunit (PIK3CA) is frequently mutated or amplified in a variety of cancers including ovarian and colon and this protein is one of the PI3K mutants . PIK3CA gene copy number is increased in over 30% of ovarian cancers and this leads to increased PI3-kinase activity. Furthermore, the activity of p110a is essential for vascular development and inactivation of p110a leads to severe defects in angiogenic sprouting and vascular remodeling .
Quantity	10 µg
Regulatory	RUO
Source	Insect cells
Host	Human
Biological Activity Comment	The specific activity of PI3K (p110a/p85a) was determined to be 52 nmol/min/mg as per activity assay protocol.

Weight	86.0 kDa, 111.0 kDa

Format	Liquid 50mM sodium, pHosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
Purity	70% - 90%
Storage	Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10900511	Z500289	10µg	$261.11		Add to Cart

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