Please refer to the printed manual for detailed information.
Background
PTGDS; also known as L-PGDS; belongs to the calycin superfamily;lipocalin family. Lipocalins share limited regions of sequence homology and a common tertiary structure architecture. They transport small hydrophobic molecules such as steroids; bilins; retinoids; and lipids. PTGDS is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of PGH2 to PGD2. It is involved in smooth muscle contraction/relaxation and a variety of central nervous system functions. PTGDS may have an anti-apoptotic role in oligodendrocytes. It binds small non-substrate lipophilic molecules; including biliverdin; bilirubin; retinal; retinoic acid and thyroid hormone; and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.
Reactivity
Human
Tag
C-His
Description
A DNA sequence encoding the human PTGDS (P41222) (Met1-Gln190) was expressed with a polyhistidine tag at the C-terminus.
Formulation
Lyophilized from sterile PBS; pH 7.4
Host
HEK293 Cells
Accession Number
P41222
Endotoxin Level
< 1.0 EU per ug of the protein as determined by the LAL method.
Mol Weight
20.1 kDa
Mw(kda)
20.1 kDa
Sequence Info
Met 1-Gln190
Shipping
This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.