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Home / Proteins & Peptide

Recombinant Human MFG-E8/lactadherin/MFGE8 Protein (His Tag)(Active)

SKU : BHP10302947

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH031387
Alternative Names	BA46;EDIL1;HMFG;hP47;HsT19888;MFG-E8;MFGM;OAcGD3S;SED1;SPAG10
Reconstitution	Please refer to the printed manual for detailed information.
Background	MFG-E8, also known as lactadherin and MFGE8, contains 1 EGF-like domain and 2 F5/8 type C domains. It also contains a phosphatidylserine (PS) binding domain, as well as an Arginine-Glycine-Aspartic acid motif, which enables the binding to integrins. It binds PS, which is exposed on the surface of apoptotic cells. MFG-E8 is expressed in mammary epithelial cell surfaces and aortic media. Overexpression of MFG-E8 can be found in several carcinomas. MFG-E8 has an opsonization of the apoptotic cells and binding to integrins on the surface of phagocytic cells. It also mediates the engulfment of the dead cell. MFG-E8 plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. It promotes VEGF-dependent neovascularization and contributes to phagocytic removal of apoptotic cells in many tissues. It also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner.
Reactivity	Human
Tag	C-His
Description	A DNA sequence encoding the human MFGE8 isoform 1 (Q08431-1) (Met 1-Cys 387) was fused with a polyhistidine tag at the C-terminus.
Formulation	Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% gly
Host	Baculovirus-Insect Cells
Accession Number	Q08431-1
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Bioactivity	When 5 x 10E4 cells/well are added to Recombinant Human MFG-E8 coated plates (12.5 ug/mL, 100 uL/well), 45-85% cells will adhere after 1 hour at 37?.
Mol Weight	42 kDa
Mw(kda)	42 kDa

Sequence Info	Met 1-Cys 387

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 80 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10302947	PKSH031387	100ug	$732		Add to Cart

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