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Home / Proteins & Peptide

Recombinant Human Mesothelin/MSLN Protein (aa 37-286, Fc Tag)

SKU : BHP10303776

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH032747
Alternative Names	Megakaryocyte potentiating factor; mesothelin; Pre-pro-megakaryocyte-potentiating factor; soluble MPF mesothelin related protein;CAK1; MPF; MSLN; SMR; CAK1; CAK1 antigen
Reconstitution	Please refer to the printed manual for detailed information.
Background	Mesothelin is a cell surface glycoprotein whose expression is limited to mesothelial cells of the serosa (pleura; pericardium; and peritoneum) and epithelial cells of the trachea; tonsils; fallopian tube; and kidneys. Mesothelin plays an important role in cell survival; proliferation; migration; invasion; tumor progression; and resistance to chemotherapy. The overexpression of mesothelin can activate NF-?B and signal transducer and activator of transcription 3 (Stat3); inhibit apoptotic signaling and TNF-alpha-induced apoptosis; and accelerate the G1S transition. Mesothelin is also found overexpressed in various cancers; including malignant mesothelioma; pancreatic or ovarian carcinoma; sarcomas and in some gastrointestinal or pulmonary carcinomas. As a result of its limited expression in normal tissues; mesothelin has been reported as an ideal tumor-associated marker for the development of targeted therapy.
Reactivity	Human
Tag	C-Fc
Description	Recombinant Human Mesothelin is produced by our Mammalian expression system and the target gene encoding Leu37-Arg286 is expressed with a Fc tag at the C-terminus.
Formulation	Lyophilized from a 0.2 um filtered solution of PBS; pH7.4.
Host	Human Cells
Accession Number	Q13421
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Mol Weight	53.9 kDa
Mw(kda)	53.9 kDa

Sequence Info	Leu37-Arg286

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 95 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10303776	PKSH032747	10ug	$92		Add to Cart
BHP10303776	PKSH032747	50ug	-		Add to Cart

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