MELK or maternal embryonic leucine zipper kinase is a member of the CAMKL kinase family. MELK is a key regulator of the proliferation of malignant brain tumors including their stem cells . MELK transcript abundance correlates with malignancy grade in human astrocytomas and represents a therapeutic target for the management of the most frequent brain tumors in adult and children. MELK also plays a role in mammary carcinogenesis through inhibition of the pro-apoptotic function of Bcl-GL . Therefore, the kinase activity of MELK could be a promising molecular target for development of therapy for patients with breast cancers.
Quantity
10 µg
Regulatory
RUO
Source
Insect cells
Host
Human
Biological Activity Comment
The specific activity of MELK was determined to be 210 nmol /min/mg as per activity assay protocol.
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Immunogen Species
Homo Sapiens (Human)
Reviews of Recombinant Human MELK (1-550aa) (N-GST tag)