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Home / Proteins & Peptide

Recombinant Human Interleukin-22/IL-22 Protein (C-hIgG2 Fc)(Active)

SKU : BHP10303669

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH032632
Alternative Names	Interleukin-22; IL-22; Cytokine Zcyto18; IL-10-related T-cell-derived-inducible factor; IL-TIF; IL22;IL-D110;IL-TIF;ILTIF;TIFa;TIFIL-23;zcyto18
Reconstitution	Please refer to the printed manual for detailed information.
Background	Interleukin-22(IL-22) is a member of a group of the IL-10 family; a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells. IL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction. It can initiate and regulate innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 along with IL-17 likely plays a role in the coordinated response of both adaptive and innate immune systems. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. Biological activity of IL-22 is initiated by binding to a cell-surface complex consisting of IL-22R1 and IL-10R2 receptor chains. IL-22 biological activity is further regulated by interactions with a soluble binding protein; IL-22BP. IL-22BP and an extracellular region of IL-22R1 share sequence similarity. In some cases; the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by cytokine IL-17A.
Reactivity	Human
Tag	C-hIgG2 Fc
Description	Recombinant Human Interleukin-22 is produced by our Mammalian expression system and the target gene encoding Ala34-Ile179 is expressed with a hIgG2 Fc tag at the C-terminus.
Formulation	Lyophilized from a 0.2 um filtered solution of PBS; pH7.4.
Host	Human Cells
Accession Number	Q9GZX6
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Bioactivity	Measured by its ability to induce IL-10 secretion in COLO 205 human colorectal adenocarcinoma cells. The ED50 for this effect is 90.41 ng/ml.
Mol Weight	43.4 kDa
Mw(kda)	43.4 kDa

Sequence Info	Ala34-Ile179

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 95 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10303669	PKSH032632	10ug	$178		Add to Cart
BHP10303669	PKSH032632	50ug	$523		Add to Cart

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