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Home / Proteins & Peptide / Recombinant Protein

Recombinant Human Interleukin-1 receptor antagonist protein (IL1RN) (Active)

BHP10506466
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Involvement In Disease Microvascular complications of diabetes 4 (MVCD4); Interleukin 1 receptor antagonist deficiency (DIRA)
Subcellular Location Isoform 1: Secreted, SUBCELLULAR LOCATION: Isoform 2: Cytoplasm, SUBCELLULAR LOCATION: Isoform 3: Cytoplasm, SUBCELLULAR LOCATION: Isoform 4: Cytoplasm
Uniprot P18510
Database Links

HGNC:6000

OMIM:147679

KEGG:hsa:3557

STRING:9606.ENSP00000259206

UniGene:Hs.81134
Function Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.
Research Area Immunology
Tissue Specificity The intracellular form of IL1RN is predominantly expressed in epithelial cells.
Antigen IL1RN
Purity Greater than 95% as determined by SDS-PAGE.
Storage Buffer Lyophilized from a 0.2 μm Filtered 50 mM Tris-HCl, 0.2 M NaCl, pH 7.5
Immunogen Species Homo Sapiens (Human)
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BHP10506466 CSB-AP004601HU 10ug $78
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BHP10506466 CSB-AP004601HU 50ug $194
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BHP10506466 CSB-AP004601HU 500ug $1190
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BHP10506466 CSB-AP004601HU 1mg $1702
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