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Home / Proteins & Peptide

Recombinant Human Integrin-linked protein kinase(ILK),partial

SKU : BHP10501676

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-RP009994h
Alternative Names	59 kDa serine/threonine-protein kinaseILK-1ILK-2p59ILK
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	1-228aa
Mol Weight	30.0kDa
Nature	recombinant
Protein Description	Partial

Subcellular Location	Cell junction, focal adhesion, Cell membrane, Peripheral membrane protein, Cytoplasmic side, Cell projection, lamellipodium, Cytoplasm, myofibril, sarcomere
Uniprot	Q13418, Q13418
Database Links	HGNC:6040 OMIM:602366 KEGG:hsa:3611 STRING:9606.ENSP00000299421 UniGene:Hs.706355
Function	Receptor-proximal protein kinase regulating integrin-mediated signal transduction
Pathway	PPAR signaling pathway; Focal adhesion
Protein Families	Protein kinase superfamily, TKL Ser/Thr protein kinase family
Research Area	Signal Transduction
Tissue Specificity	Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver.
Weight	30.1kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10501676	CSB-RP009994h	1mg	$1812		Add to Cart
BHP10501676	CSB-RP009994h	100ug	$419		Add to Cart
BHP10501676	CSB-RP009994h	20ug	$224		Add to Cart

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