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Home / Proteins & Peptide

Recombinant Human IL3RA/CD123 Protein (His Tag)(Active)

SKU : BHP10303004

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH031551
Description	A DNA sequence encoding the human IL3RA (NP_002174.1) extracellular domain (Met 1-Arg 305) was expressed, with a C-terminal polyhistidine tag.
Alternative Names	CD123;hIL-3Ra;IL3R;IL3RAY;IL3RX;IL3RY
Reconstitution	Please refer to the printed manual for detailed information.
Background	Interleukin-3 receptor subunit alpha, also known as IL-3 receptor subunit alpha, IL-3R-alpha, CD123, and IL3RA, is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 5 subfamily. The specific alpha subunit of the interleukin-3 receptor (IL-3Ralpha, CD123) is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias. The WSXWS motif of IL3RA appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box one motif of IL3RA is required for JAK interaction and / or activation. IL3RA represents a unique marker for primitive leukemic stem cells. Targeting of IL3RA may be a promising strategy for the preferential ablation of AML cells. Aberrant IL3RA expression is a good marker for monitoring of minimal residual disease. IL3RA is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias. Recent studies have shown that interleukin-3 receptor alpha (CD123) is highly expressed on leukemia stem cells of patients with acute myeloid leukemia, and is correlated with tumor load and poor prognosis. CD123 was highly expressed in the bone marrow of the patients with myelodysplastic syndrome (MDS), significantly correlated with the proportion of bone marrow blasts, and thus might be the marker of MDS malignant clone. IL3RA is also a useful new marker for distinguishing B-cell disorders with circulating villous lymphocytes as its expression is characteristic of typical hairy cell leukemia (HCL) with high sensitivity and specificity.
Reactivity	Human
Tag	C-His
Formulation	Lyophilized from sterile PBS, pH 7.4
Host	HEK293 Cells
Accession Number	NP_002174.1
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Bioactivity	Measured by its binding ability in a functional ELISA. Immobilized human IL3 at 20 ug/ml (100 ul/well) can bind biotinylated human IL3RA with a linear ranger of 0.32-1.6 ug/ml.
Mol Weight	34.5 kDa
Mw(kda)	34.5 kDa

Sequence Info	Met 1-Arg 305

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 95 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10303004	PKSH031551	100ug	$1024		Add to Cart
BHP10303004	PKSH031551	1mg	$6665		Add to Cart

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