Please refer to the printed manual for detailed information.
Background
The interleukin-27 receptor is a type I cytokine receptor for interleukin-27. It is a heterodimer composed of the interleukin 27 receptor, alpha subunit and glycoprotein 130. WSX-1/IL-27R, a class I cytokine receptor that is homologous to the beta2 chain of the IL-12R in both sequence and structure, is highly expressed by resting/naive CD4+ T cells and CD8+ T cells. WSX-1/IL-27R belongs to the IL-6/IL-12 family of cytokines and induced proliferation of naive CD4(+) T cells and the generation of a Th1-type adaptive immune response. WSX-1/IL-27R functions as a receptor for IL27. IL-27 not only contributes to the development of an adaptive immune response through its action on CD4(+) T cells, it also directly acts on cells of the innate immune system. WSX-1/IL-27R requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. It is involved in the regulation of Th1-type immune responses. IL-27R also appears to be involved in innate defense mechanisms. IL27RA is essential for transcriptional activation of STAT1 and for augmenting the induction of T-bet expression during initiation of Th1 cell differentiation.
Reactivity
Human
Tag
C-Fc
Description
A DNA sequence encoding the extracellular domain (Met 1-Arg 514) of human IL27Ralpha (NP_004834.1) was fused with the Fc region of human IgG1 at the C-terminus.
Formulation
Lyophilized from sterile PBS, pH 7.4, 8% trehalose, 8% mannitol
Host
HEK293 Cells
Accession Number
NP_004834.1
Endotoxin Level
< 1.0 EU per ug as determined by the LAL method.
Bioactivity
Measured by its binding ability in a functional ELISA. Immobilized human IL27 at 20 ug/ml (100 ul/well) can bind human IL27Ra with a linear ranger of 0.064-1.6 ug/ml.
Mol Weight
79 kDa
Mw(kda)
79 kDa
Sequence Info
Met 1-Arg 514
Shipping
This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.