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Home / Proteins & Peptide

Recombinant Human IL10

SKU : BHP10900670

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Z102837
Description	IL10 is a homodimeric protein with subunits having a length of 160 amino acids. In human system IL10 is produced by activated CD8(+) peripheral blood T cells, by T helper CD4(+) T cell clones after both antigen-specific and polyclonal activation, by B cell lymphomas, and by monocytes following cell activation by bacterial lipopolysaccharides and mast cells. IL10 down-regulates the function of Th1 and Th2 cells. IL10 inhibits the synthesis of a number of cytokines such as IFN-gamma, IL2 and TNF-beta in Th1 T helper subpopulations of T cells but not of Th2 T helper cells. This activity is antagonized by IL4. The inhibitory effect on IFN-gamma production is indirect and appears to be the result of a suppression of IL12 synthesis by accessory cells. Recombinant Human IL10 is expressed in human 293 cells as a non-covalent homodimeric glycoprotein
Alternative Names	Cytokine synthesis inhibitory factor ; CSIF ; B-TCGF ; TGIF ; IL-10
Quantity	100 µg
Regulatory	RUO
Source	HEK293
Host	Human
Endotoxin Level	<1 EU/µg of recombinant protein as determined by the LAL method
Biological Activity Comment	The EC(50) as determined by the dose-dependent stimulation of the proliferation of MC/9 cells (mouse mast cell line) in the presence of 200 pg/mL IL-4 was found to be ≤1.5ng/mL.

Weight	17 kDa, non-disulfide bonded homodimer, glycosylated

Description	A quick spin of the vial followed by reconstitution in sterile 1xPBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA).
Format	Lyophilized Powder 10mM Tris-HCl pH 7.4 + 150mM NaCl
Purity	>95% as determined by SDS-PAGE
Storage	The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months. Avoid repeated freeze/thaw cycles.

Immunogen Species	Homo Sapiens (Human)

MSDS	Growth Factors, Cytokines & Kinases MSDS
Other	Growth Factor and Cytokine Brochure

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SKU	Supplier No.	Size	Your price	Quantity
BHP10900670	Z102837	100µg	$1830.50		Add to Cart

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