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Home / Proteins & Peptide

Recombinant Human IgG4-Fc Protein (aa 104-327, Leu325Pro)

SKU : BHP10304604

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH033651
Description	Recombinant Human IgG4-Fc is produced by our Mammalian expression system and the target gene encoding Pro104-Lys327(Leu325Pro) is expressed.
Alternative Names	Ig gamma-4 chain C region,IgG4 Fc;IGHG4
Reconstitution	Please refer to the printed manual for detailed information.
Background	As a monomeric immunoglobulin that is predominately involved in the secondary antibody response and the only isotype that can pass through the human placenta; Immunoglobulin G (IgG) is synthesized and secreted by plasma B cells; and constitutes 75% of serum immunoglobulins in humans. IgG antibodies protect the body against the pathogens by agglutination and immobilization; complement activation; toxin neutralization; as well as the antibody-dependent cell-mediated cytotoxicity (ADCC). IgG tetramer contains two heavy chains (50 kDa ) and two light chains (25 kDa) linked by disulfide bonds; that is the two identical halves form the Y-like shape. IgG is digested by pepsin proteolysis into Fab fragment (antigen-binding fragment) and Fc fragment ("crystallizable" fragment). IgG1 is most abundant in serum among the four IgG subclasses (IgG1; 2; 3 and 4) and binds to Fc receptors (FcgammaR ) on phagocytic cells with high affinity. Fc fragment is demonstrated to mediate phagocytosis; trigger inflammation; and target Ig to particular tissues. Protein G or Protein A on the surface of certain Staphylococcal and Streptococcal strains specifically binds with the Fc region of IgGs; and has numerous applications in biotechnology as a reagent for affinity purification. Recombinant IgG Fc Region is suggested to represent a potential anti-inflammatory drug for treatment of human autoimmune diseases.
Reactivity	Human
Formulation	Lyophilized from a 0.2 um filtered solution of 20mM PB;150mM NaCl;pH7.4.
Host	Human Cells
Accession Number	P01861
Endotoxin Level	< 1.0 EU per ?g as determined by the LAL method.
Mol Weight	25.1 kDa
Mw(kda)	25.1 kDa

Sequence Info	Pro104-Lys327(Leu325Pro)

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 95% as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10304604	PKSH033651	10ug	$37		Add to Cart
BHP10304604	PKSH033651	50ug	-		Add to Cart

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