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Home / Proteins & Peptide

Recombinant Human herpesvirus 1 ICP47 protein(US12)

SKU : BHP10502623

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-YP360979HWY
Alternative Names	Immediate-early protein IE12Immediate-early-5Infected cell protein 47US12 proteinVmw12
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Plays a role in the inhibition of host immune response. Binds specifically to transporters associated with antigen processing (TAP), thereby blocking peptide-binding and translocation by TAP as well as subsequent loading of peptides onto MHC class I molecules. pty MHC I molecules are retained in the endoplasmic reticulum and ultimately directed to proteasomal degradation. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes.
Source	Yeast
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: ICP47 protein; Alternative name(s): Immediate-early protein IE12; Immediate-early-5; Infected cell protein 47; US12 protein; Vmw12
Expression Region	1-88aa
Mol Weight	11.8kDa
Nature	recombinant
Protein Description	Full Length

Subcellular Location	Host cytoplasm, Host nucleus
Uniprot	P03170, P03170
Database Links	KEGG:vg:2703441
Function	Plays a role in the inhibition of host immune response. Binds specifically to transporters associated with antigen processing (TAP), thereby blocking peptide-binding and translocation by TAP as well as subsequent loading of peptides onto MHC class I molecules. Empty MHC I molecules are retained in the endoplasmic reticulum and ultimately directed to proteasomal degradation. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes.
Protein Families	Herpesviridae US12 family
Research Area	Others
Weight	11.79kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10502623	CSB-YP360979HWY	500ug	$1916		Add to Cart
BHP10502623	CSB-YP360979HWY	100ug	$826		Add to Cart
BHP10502623	CSB-YP360979HWY	20ug	$436		Add to Cart

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