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Home / Proteins & Peptide

Recombinant Human GRK2 (N-GST tag)

SKU : BHP10900803

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Z500155
Description	GRK2 or ADRBK1 is a ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G protein-coupled receptors. GRK2 phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart . RAF kinase inhibitor protein RKIP is a physiologic inhibitor of GRK2 . After stimulation of G protein-coupled receptors, RKIP dissociates from its known target, RAF1 to associate with GRK2 and block its activity.
Alternative Names	ADRBK1 ; BARK1 ; BETA-ARK1 ; FLJ16718
Tag	N-GST tag
Quantity	10 µg
Regulatory	RUO
Source	Insect cells
Host	Human
Biological Activity Comment	The specific activity of GRK2 was determined to be 5.3 nmol /min/mg as per activity assay protocol.

Weight	102.0 kDa

Format	Liquid 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Purity	70% - 90%
Storage	Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10900803	Z500155	10µg	$361.11		Add to Cart

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